This book is based on, an in-depth filmed conversation between Howard Burton and Jay Gargus, Professor of Physiology, Biophysics and Pediatrics and Director of the Center for Autism Research and Translation at UC Irvine. This wide-ranging conversation examines the recent explosion in our genetic understanding and its implications for the future of medicine, together with the importance of understanding the underlying molecular mechanisms, in order to successfully treat a wide range of genetic disorders. Prof. Gargus focuses on autism, dispelling myths associated with the condition, advocating why a treatment should be actively pursued, and illustrating what we can learn from the recent breakthrough in cystic fibrosis research.
This carefully-edited book includes an introduction, Machine Repair, and questions for discussion at the end of each chapter: I. The Lure of Genetics- Where the action was-and still is II. Genetics 101- A basic overview III. Towards Disease- Intervening in metabolic pathways IV. Autism - Myths, current understanding and challenges V. Pathways and Pleiotropy- Searching for mechanisms VI. Reasons for Optimism- Streamlined bureaucracy and bold prognostications
