Wiley on Radiochemical Syntheses

The ultimate reference guide to the synthesis of radiopharmaceuticals “The Radiochemical Syntheses” series provides scientists and professionals with a comprehensive reference to proven synthetic methods for radiochemical reactions, along with step-by-step guidance on how to replicate these syntheses in the laboratory. Volume 1 in the series focuses on the synthesis and purification of radiopharmaceuticals in clinical use today. It brings together in one complete, self-contained volume a collection of monographs containing a wealth of practical information from across the literature, demonstrating in meticulous detail how to prepare radiopharmaceuticals for positron emission tomography (PET) imaging, especially in tumor studies, cardiology, and neuroscience. Readers have key experimental details culled from the literature at their fingertips, greatly simplifying the process of qualifying a site for the clinical production of new radiopharmaceuticals.

This book describes methods and procedures for preparing PET radiopharmaceuticals and highlights new methods for conducting radiochemical reactions with carbon-11 (C11) and fluorine-18 (F18), which are two of the most commonly used radionuclides in positron emission tomography (PET) imaging. • Provides reliable methods for radiochemical syntheses and reactions, including all essential information to duplicate the procedure • Eliminates the time-consuming process of searching journal articles and extracting pertinent details from lengthy experimental sections or supporting information • Focuses on an emerging and important area for pharmaceutical and medical applications • Encompasses technical, regulatory, and application aspects • Includes solid-phase radiochemistry, transition-metal catalyzed radiochemistry, microfluidics, click chemistry, green radiochemistry and new strategies for radiopharmaceutical quality control