The medics and midwives of Nonnatus House are entering a bold and innovative era. They face unexpected challenges as the population shifts, rules change, and old diseases come back to haunt them.
As Christmas approaches, a bout of influenza sweeps through both Nonnatus House and the Turner family. Later, Mother Mildred declares that God is calling her to set up a branch house in the Outer Hebrides.
Dr. Turner, Shelagh, Mother Mildred, Trixie, Sister Julienne, Valerie and Lucille set off on their journey to the Outer Hebrides, where they are to stay in a freezing cold converted church.
Dr. Turner and Nurse Crane must deal with an alarming outbreak of diphtheria. Fred finds an abandoned baby in a dustbin, and the team must help locate its mother.
Leading up to Mother's Day, the team must survive Lent and are forced to give up more than just cigarettes and sugar. Meanwhile, Dr. Turner puzzles over a mysterious string of symptoms.
Four new doctors arrive at Nonnatus House and ruffle some feathers. Fred and Reggie try to help an old man and his pigeons, while Dr. Turner tries to solve the old man's cough.
Sister Frances struggles to persuade the wife of a cancer patient to accept help, and as the nation obsesses over The Sound of Music, Sister Julienne considers the privileges of being a nun.
Maya's adoption by the Turners comes under threat when someone from her past appears. Valeriea's cousin's baby has a devastating illness, and Kevin returns to work with Dr. Turner.